Retinoids Modulate Thioacetamide-Induced Acute Hepatotoxicity
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Ipomoea aquatica extract shows protective action against thioacetamide-induced hepatotoxicity.
In the Indian system of traditional medicine (Ayurveda) it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA)-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD)...
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In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA dose resulted in a marked progression of injury and 100% lethality. The objecti...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2014
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfu045